返回首页| 加入收藏| 联系我们  
 
本站首页
产品中心
一定发电脑版官方网站
关于我们
成功案例
人才战略
服务支持
联系我们
   
 
 
  分析仪器类
  电位测量
  粒度测量
  Zeta电位测量
  光散射系统
  分子量测量

  泵阀类
  台湾ASSOMA磁力泵
  德国VERDER泵
  意大利赛高(SEKO)计量泵
  韩国千世(KEMPION)计量泵
  台湾上泰(SUNTEX)仪器
  长河清远成套设备
  Hydra-Cell高压隔膜泵

 
  首页 >> 一定发电脑版官方网站 >> EDF777.COM >> Nanobrook Omni测量应用案例-97
  
Nanobrook Omni测量应用案例-97
[ 发布时间:2019-04-11 | 浏览数:50 ]

     

文献名:Biodistribution, excretion, and toxicity of polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles in mice via different administration routes  

 

作者: Jie Yu,ab  Wenyan Yin,b  Tao Peng,b  Ya-nan Chang,b  Yan Zu,b  Juan Li,b  Xiao He,b  Xiaoyan Ma,a  Zhanjun Gub  and  Yuliang Zhaobc   

 a Key Laboratory of Polymer Science and Technology, School of Science, Northwestern Polytechnical University, Xi'an, China

b Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety, Institute of High Energy Physics, Chinese Academy of Sciences (CAS), Beijing 100049, China

c CAS Center for Excellence in Nanoscience, National Center for Nanoscience and Technology of China, Beijing, China

 

摘要:Upconversion nanoparticles (UCNPs) have drawn much attention in biomedicine, and the clinical translation of UCNPs is closely related to their toxicity and metabolism in vivo. In this study, we chose polyethyleneimine modified NaYF4:Yb,Er upconversion nanoparticles (abbreviated as PEI@UCNPs) to systematically study the biodistribution in mice using intravenous (i.v.), intraperitoneal (i.p.), and intragastric (i.g.) administration. The i.p. injected PEI@UCNPs exhibited obvious accumulation in the spleen within 30 days. Comparably, PEI@UCNPs via i.g. administration exhibited an accumulation that decreased with time in various body tissues and were found mainly in the ileum and cecum but were rather low in concentration in the other examined organs. For the i.v. injected group, the UCNPs exhibited an obvious clearance from the body within 30 days and the accumulation in the spleen gradually decreased. Furthermore, 64Cu labeled PEI@UCNPs were i.v. injected for real-time photon emission computed tomography (PET) imaging to further confirm the biodistribution in mice. Afterward, the excretion routes of the PEI@UCNPs were evaluated. For i.p. injected groups, the UCNPs were slowly and partly excreted via feces and urine for 30 days, and a large number of the UCNPs were steadily excreted via feces for the i.v. group, suggesting that the UCNPs via i.v. injection can be potentially used for imaging and therapy studies in vivo. However, for the i.g. administrated group, most of the UCNPs were excreted through feces within 48 h. Hematology, body weight, and biochemical analysis were used to further quantify the potential toxicity of the UCNPs, and results indicated that there was no over toxicity of the UCNPs in mice at the tested period. This work suggests that the clearance and excretion capabilities of PEI@UCNPs are particularly dependent on their administration routes.


 

 
  公司介绍 | 产品中心 | 服务支持 | 联系我们 | GoogleSitemap
一定发网址.All rights reserved.一定发网址 版权所有
京ICP备05017992号-1